Neostimulation with mesofiller® nexha and mesohyal® redenx
a new generation of injectable therapies for correction and skin quality
Modern aesthetic medicine strays away from the idea of a filler as a product, whose only purpose is to “fill” a line or create volume. Patients look for natural results, better skin quality and change, which does not look like excessive amounts of hyaluronic acid.
This is the concept on which mesofiller® nexha by mesoestetic® was built – a new generation of dermal fillers, which combine cross-linked hyaluronic acid with succinic acid to combine immediate aesthetic corrections with an effect on the quality of the treated tissue.
This is an approach which can be defined as neostimulation – the filler creates the needed volume, projection or structural support, but at the same time the formula is created to help the biological processes in the aging skin.
mesofiller nexha – when the filler not only reshapes, but works for skin quality
What is different in mesofiller nexha?
The foundation of the nexha products is the well-known hyaluronic acid. It provides the immediate effect which we expect from a dermal filler – volume restoration, smoothing of lines, shaping lips, improvement of proportions and structuring of the face. The difference is the addition of succinic acid in the 3D matrix of the filler. As the gel is being reabsorbed, it is slowly released in the tissue.
It is this combination of hyaluronic acid and succinic acid that is the object of a scientific paper published in 2025. The research focuses on aging dermal fibroblasts and adypocites and it shows effects on processes connected to cellular aging, mytophagy, cellular communication and gene expression in the extracellular matrix.
In practice, the idea is simple: not only adding something to the face, but improving the way in which the tissues themselves look.
Filler + neostimulation – a new approach to natural rejuvenation
The classical filler can correct volume loss or a specific wrinkle immediately. But skin aging is not only caused by loss of volume.
In time, changes occur in:
- Density and elasticity of the skin
- Fat compartments under the skin
- Structure and support of tissues
- Hydration
- Skin texture
- Cells’ ability to function optimally.
This is why the modern approach to the face is more complex.
In mesofiller nexha the immediate mechanical correction of hyaluronic acid is combined with a strategy aimed towards better tissue quality using succinic acid. This makes the range interesting for patients who don’t only want “more volume”, but a fresher, tighter and natural looking face.
mesofiller nexha product range
mesofiller nexha lips – beautiful lips and attention to tissue quality
mesofiller nexha lips is especially developed for the lips and perioral zone. The formula contains cross-linked hyaluronic acid with a concentration of 20mg/ml and is created for shaping and remodeling of the lips, as well as lip rejuvenation.
This allows for a finer than standard approach for “lip filler application”.
Depending on the individual anatomy and the desired result, the following can be achieved:
- Better contour definition
- Medium projection
- Restoration of volume lost in time
- Improved proportions
- Fresher appearance of the lips.
The clinical studies by mesoestetic in 30 patients show not only immediate volumizing effects, but also an improvement in skin quality of the lips in time. This is why nexha lips is especially interesting for patients who want their lips to look better in the long term – without fine lines and with optimal hydration, not only better definition.
mesofiller nexha lift – structure, tightness and correction of deep lines
mesofiller nexha lift is created for the more visible signs of aging – deep lines, sagging and a need for structural support. The formula contains 25 mg/ml of cross-linked hyaluronic acid, which is enriched with succinic acid, NCTC 109 and DMAE.
Depending on the indications, the following can be achieved with the product:
- Correction of deep facial lines and wrinkles
- Improvement of contour tightness
- A decrease in visible sagging
- Remodeling of the mid-third of the face (cheekbones).
The goal is not to make the face look “filled”, but to work strategically in the zones in which the loss of structural support changes the contour and creates a tired or sagging appearance.
mesofiller nexha volume – restoration of lost volume
When the main problem is loss of volume and projection, mesofiller nexha volume provides structural correction. It contains 25 mg/ml of cross-linked hyaluronic acid and is developed for optimal projection of the tissue. Its rheology allows for lifting and structuring of the treated zone, and a slow-release succinic acid is also contained in its matrix. The appropriate zones and the technique are always determined by a doctor after analysis of the face. When used correctly, this product can restore the lost structure without making the face look heavy or excessively volumized.
With this product, the following can be achieved:
- Immediate restoration of volume in the middle and lower facial third;
- Improvement in tissue density
- Improvement in skin quality
mesofiller nexha aox – fine correction + antioxidant formula
mesofiller nexha aox is aimed for finer and medium lines and imperfections in the lower two thirds of the face. It contains 20mg/ml of cross-linked hyaluronic acid, succinic acid, vitamin C and idebenone. The products combined the immediate smoothing effect of hyaluronic acid with a complex of active components chosen to focus on skin quality. This makes it especially interesting for patients who do not experience considerable volume loss, but early signs of aging, fine lines, texture changes and a desire for a fresher appearance.
The unique complex of 3 antioxidants not only corrects fine lines, but also:
- Improves skin metabolism, regulates sebum and decreases inflammation (with succinic acid)
- Brightens the complexion, evens out pigmented lesions and stimulates collagen synthesis (with vitamin C)
- Neutralizes free radicals, stimulates regeneration, provides a glowing appearance and evens out the tan (with idebenone)
mesohyal redenx – when we are not looking for volume, but for skin density
Not every patient needs filler. Sometimes the face doesn’t need any additional projection or shape correction, but it needs improvement in density, tightness and skin quality.
This is where mesohyal redenx’s role is.
This is an intradermal therapy with 15 mg/ml of hyaluronic acid, combined with tripeptide and tetrapeptide. The product is created to reduce the so-called gravitational lines and to improve density and rigour of the skin. With redenx, we are not aiming for the classical effect of the dermal filler. The aim is to redensify the skin – for it to look denser, tighter, well hydrated and with better overall quality. mesoestetic shares results of their clinical trials, according to which mesohyal redenx assists cellular activity and skin regeneration.
Which product is suitable for you?
This does not depend solely on age.
Two patients of the same age can have completely different needs – in one, the leading problem could be volume loss in the middle third of the face, in the second – sagging, in the third – changes in the lips, and in the fourth – decreased density and skin quality. This is why the correct approach is chosen after a medical consultation and assessment of the anatomy, proportions, mimic and tissue quality.
mesofiller nexha and mesohyal redenx allow us to think beyond “how many mililiters of filler are needed” and to aim towards a more precise question: what does the face actually need?
The goal is not simply correction.
The goal is a natural appearance with better skin and tissue quality.
